Research Grade Plasmid DNA
Domestic. High-Purity. Global-Market Prices.
Accelerate your preclinical programs without compromise. Novel Bio delivers high-purity plasmid DNA through optimized, FDA-proven E. coli manufacturing platforms, providing the domestic supply chain security you need at costs competitive to ex-US vendors. We support everything from microgram discovery to gram-scale animal studies with rapid 72-hour starting turnarounds that keep your development on track.
Technical Expertise for Complex Genetic Payloads
Beyond standard production, Novel Bio specializes in the high-fidelity manufacturing of challenging constructs that derail discovery timelines. Our scientists leverage a deep understanding of downstream applications, including mRNA templates, AAV vectors, and lentiviral systems, to ensure your sequences are delivered with absolute integrity.
Managing complex features: We utilize specialized protocols to stabilize high-complexity elements such as extended poly(A) tails and ITR sequences, ensuring reliability where traditional platforms fail.
Integrated R&D workflows: We provide end-to-end support, including gene synthesis, complex cloning, and advanced chromatographic purification, with process consistency that scales as your project matures.
Built for clinical translation: Every R&D Grade project uses the same manufacturing framework as our High Quality (HQ) and GMP production. When your lead candidate advances, you get a validated tech transfer, not a ground-up process redesign.
Exceptional Pricing and Turnaround Time
Guaranteed yields delivered on time and at lower costs. We can scale from a variety of starting materials such as glycerol stock, plasmid DNA, and plates. Starting pricing and turnaround times for multi-milligram scale delivery are listed below.
*Starting turnaround time and pricing based on high-copy-number, well-behaved plasmids
Analytical Rigor: Phase-Appropriate Quality Control
Quality control that fits. We provide three tiered QC packages designed to balance speed, cost, and data integrity. Get the analytical depth your current work demands, while building a documented foundation for future regulatory filings.
Essential QC Package
Flexible analytics for rapid-cycle discovery work. The critical purity and identity data you need for fast characterization and immediate release, minus the cost of assays your early-stage work doesn't require.
Standard QC Package
Comprehensive specifications for advanced preclinical applications. Includes full analytical characterization with endotoxin clearance and supercoiled percentage determination; ideal for in vivo studies and sensitive work.
Premium QC Package
Fully customizable analytics tailored to your unique construct or application. Work directly with our team to design a testing strategy that addresses your specific needs, such as enhanced supercoiled purity and ultra-low endotoxin thresholds.
R&D Grade Technical Specifications
1. Clients selecting Essential QC can request a basic report limited to DNA purity by absorbance or a more comprehensive report.
2. While Novel Bio does not guarantee a supercoiled percentage for Essential and Standard QC, according to our internal data, we typically observe a supercoiled DNA content of 80% or higher at all QC Levels. Novel Bio can offer an upgrade for Premium QC to achieve a greater supercoiled percentage. This additional stringency is available only for larger scale preparations and is a customized quote.
3. While Novel Bio does not guarantee a specific endotoxin clearance for Essential QC, according to our internal data, we typically observe endotoxin clearance of < 10 EU/ug. A 10 EU/ug endotoxin is sufficient for most standard cell line transfections and many standard molecular biology applications. Our Standard QC offers an advanced clearance of 0.1 EU/ug (< 100 EU/mg) for more sensitive applications, such as in vivo research. Novel Bio can offer an upgrade for Premium QC to achieve even higher endotoxin clearance.
4. Residual Host gDNA via NGS Sequencing is available only on plasmid DNA prepared from E. coli hosts.
Optional R&D Grade QC & Add-Ons
Novel Bio offers additional quality assessments and ancillary services (such as bioburden testing, mycoplasma screening, and glycerol stock archiving) for R&D Grade plasmids. Availability varies by scale due to material requirements. Contact our team for pricing and lead times.
Bioburden (2-Day)
Mycoplasma
Residual RNA
Residual gDNA
Residual Protein
Residual Kanamycin
Your Domestic Partner in Genomic Innovation
In addition to superior pDNA, Novel Bio delivers supply chain certainty, scientific expertise, and a partnership built for long-term collaboration
Domestic security and data integrity: By centralizing manufacturing in the US, we eliminate the logistical volatility and IP risks associated with international shipping. This ensures predictable timelines and absolute data transparency for your most critical genetic assets.
Direct access to senior scientists: We don't cut corners. Our technical team is composed of veteran scientists who specialize in resolving purification bottlenecks and complex sequence instabilities, ensuring reliable delivery where standard providers struggle.
Alignment across the life cycle: We actively support your program’s evolution. From optimizing early-stage documentation to ensuring your processes are ready for future scale-up, we provide a strategic partnership that follows your journey from the research bench to the patient’s bedside.
Integrated Support for Downstream Success
Novel Bio goes beyond manufacturing to provide the technical infrastructure that de-risks your development pathway. We integrate specialized services directly into your workflow by optimizing processes, building data packages, and establishing the foundation for clinical-grade production.
Process development and optimization: We refine manufacturing parameters to maximize yield, purity, and cost-efficiency, ensuring your process is production-ready when you need to scale.
Stability and growth screening: Our team conducts rigorous plasmid stability and host strain assessments to identify and eliminate expression issues before they derail your timeline.
Research cell bank (RCB) establishment: Secure your manufacturing consistency with professionally managed cell banking, providing a verified, traceable source for every future production run.
Transparent documentation: Detailed manufacturing and release reports deliver the data integrity and traceability you need for regulatory submissions, tech transfers, and internal quality reviews.
Clear path to clinical scale: Every R&D project is designed with scale-up in mind. When your candidate advances, you receive a validated transition to High Quality (HQ) or GMP production, enabling seamless technical transfer.